Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.
The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research
Sep 6, 2022: Congratulations, Stephen, for obtaining an Ambizione Grant from SNSF that will allow you to pursue your project on chromatin dynamics! Jun 7, 2022: How the C. elegans oscillator ensures size uniformity in animals – Ben’s paper now out here, and a summary at the FMI Website or Ben’s thread on Twitter. Apr… Continue reading Lab news
2023 Meeuse, M.W.M., Hauser, Y.P., Nahar, S., Smith, A.A.T.S., Braun, K., Azzi, C., Rempfler, M., Großhans, H.* (2023) The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting EMBO J. e111895 2022 Quévillon Huberdeau, M., Nilesh Shah, V., Nahar, S., Neumeier, J., Houle, F., Bruckmann, A., Gypas, F., Nakanishi, K., Großhans, H., Meister, G., and Simard, M.J.* (2022) A specific Argonaute phosphorylation regulates the… Continue reading Publications