Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study mechanisms and function of oscillatory gene expression, cell fate control mechanisms, and microRNAs. Read more here.
The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research
Mar 5th, 2018: Shkumatava lab shows that target-directed miRNA decay modulates vertebrate behavior – read our News & Views on this exciting piece of research here. Jan 5th, 2018: Farewell Takashi! We wish you a smooth start in your new position as an Assistant Professor at the Institute of Bioorganic Chemistry Polish Academy of Science, Posnan!… Continue reading Lab news
2018 de la Mata, M., and Großhans, H. (2018) Turning the table on miRNAs. Nature Struct. Mol. Biol. 25: 195–197 2017 Miki, T.S.#,*, Carl, S.H. #, and Großhans, H.* (2017). Two distinct transcription termination modes dictated by promoters. Genes Dev. 31: 1870-1879. (# equal contribution) (Highlighted in: Otto, Nat. Rev. Genet. (2017) doi:10.1038/nrg.2017.93; Recommended Article: F1000:… Continue reading Publications