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Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study mechanisms and function of oscillatory gene expression, cell fate control mechanisms, and microRNAs. Read more here.

Research

The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research

Lab news

Sept 27th, 2019: If you prefer a linear mode of timing development, look at this preprint of Chiara’s and Florian’s work: how to coordinate events that take place during worm ‘puberty’. Sept 5th, 2019: Take a peek at our preprint showing how a developmental oscillator starts and arrests. Sept 2nd, 2019: Welcome to our new… Continue reading Lab news

Publications

2019 Welte, T.#,*, Tuck, A.C.#, Papasaikas, P., Carl, S.H., Flemr, M., Knuckles, P., Rankova, A., Bühler, M., and Großhans H.* (2019) The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1. Genes Dev. 33: 1221-1235 (# equal contribution) Aeschimann, F., Neagu, A., Rausch, M., and Großhans, H.* (2019). A single let-7 target to coordinate transition to… Continue reading Publications