Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.
The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research
May 4, 2021: We are inviting applications for a position of a technician/research assistant, to work with us on a project studying the function of the RNA-binding protein TRIM71 in mouse embryonic stem cells – see the ad here. Apr 27, 2021: We are currently seeking to strengthen the bioinformatics support in our lab. Check out… Continue reading Lab news
2021 Gudipati, R.K., Braun, K.#, Gypas, F.#, Hess, D., Schreier, J.,Carl, S.H., Ketting, R.F., Großhans, H.* Protease-mediated processing of Argonaute proteins controls small RNA association. Mol Cell doi.org/10.1016/j.molcel.2021.03.029 (# equal contribution) 2020 Meuse, M.W.M.#, Hauser, Y.P.#, Morales Moreno, L.J., Hendriks, G.-J., Eglinger, J., Bogaarts, G., Tsiairis, C., Großhans, H.* (2020) Developmental function and state transitions… Continue reading Publications