Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.
The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research
Jul 9, 2021: Identification of a first C. elegans clock component – read our preprint at bioRxiv and a thread with the key findings @LabGrosshans Jul 9, 2021: Welcome to our new postdoc, Abhi, and farewell to Chiara! May 4, 2021: We are inviting applications for a position of a technician/research assistant, to work with… Continue reading Lab news
2021 Methot, S.P.#, Padeken, J.#, Brancati, G., Zeller, P., Delaney, C.E., Gaidatzis, D., Kohler, H., van Oudenaarden, A., Großhans, H. and Gasser .* H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Nat Cell Biol (2021). https://doi.org/10.1038/s41556-021-00776-w (# equal contribution) Tsiairis, C.*, and Großhans, H.* (2021) Gene expression oscillations in C. elegans underlie a… Continue reading Publications