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Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study mechanisms and function of oscillatory gene expression, cell fate control mechanisms, and microRNAs. Read more here.

Research

The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research

Lab news

Aug 5th, 2019: TRIM71/LIN41 function in mammalian cells – see Thomas’s paper and some context and info on our fun collaboration with Alex and the Bühler lab. Jun 3rd, 2019: Farewell to Jun and Ben! May 24th, 2019: Welcome to our new postdocs, Foivos and Lucas Apr 8th, 2019: Closing date for applications to the… Continue reading Lab news

Publications

2019 Welte, T.#,*, Tuck, A.C.#, Papasaikas, P., Carl, S.H., Flemr, M., Knuckles, P., Rankova, A., Bühler, M., and Großhans H.* (2019) The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1. Genes Dev. [Epub ahead of print] (# equal contribution) Aeschimann, F., Neagu, A., Rausch, M., and Großhans, H.* (2019). A single let-7 target to… Continue reading Publications