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Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.

Research

The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research

Lab news

Jul 9, 2021: Identification of a first C. elegans clock component – read our preprint at bioRxiv and a thread with the key findings @LabGrosshans Jul 9, 2021: Welcome to our new postdoc, Abhi, and farewell to Chiara! May 4, 2021: We are inviting applications for a position of a technician/research assistant, to work with… Continue reading Lab news

Publications

2021 Tsiairis, C.*, Großhans, H.* (2021) Gene expression oscillations in C. elegans underlie a new developmental clock. Curr Top Dev Biol. 2021;144:19-43. Gudipati, R.K.*, Braun, K.#, Gypas, F.#, Hess, D., Schreier, J.,Carl, S.H., Ketting, R.F., Großhans, H.* Protease-mediated processing of Argonaute proteins controls small RNA association. Mol Cell 81:2388-2402.e8 (# equal contribution) 2020 Meuse, M.W.M.#, Hauser,… Continue reading Publications