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Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.

Research

The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research

Lab news

Apr 13, 2021: A protease that controls small RNA sorting to promote fertility – read Rajani’s paper in Mol Cell (free access till June 2) and a brief summary here. Mar 26, 2021: Did you ever wonder why individuals of a species are rather uniform in size? An oscillator-based mechanism may be the answer (at… Continue reading Lab news

Publications

2020 Meuse, M.W.M.#, Hauser, Y.P.#, Morales Moreno, L.J., Hendriks, G.-J., Eglinger, J., Bogaarts, G., Tsiairis, C., Großhans, H.* (2020) Developmental function and state transitions of a gene expression oscillator in C. elegans. Mol Syst Biol. 16: e9498 (# equal contribution) Azzi, C.#, Aeschimann, F.#, Neagu, A., Großhans, H.* (2020) A branched heterochronic pathway directs juvenile-to-adult… Continue reading Publications