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Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study developmental clocks and timers as well as RNA silencing pathways. Read more here.
Research
The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research
Lab news
Apr 8, 2022: Three more weeks to apply to our PhD or MD-PhD Program – closing date May 1st. Do apply if you are interested in elucidating the mechanisms of developmental clocks and timers with us! Mar 8, 2022: A screen that identifies C. elegans clock components – read our preprint at bioRxiv and a… Continue reading Lab news
Publications
2021 Methot, S.P.#, Padeken, J.#, Brancati, G., Zeller, P., Delaney, C.E., Gaidatzis, D., Kohler, H., van Oudenaarden, A., Großhans, H. and Gasser .* H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Nat Cell Biol (2021). https://doi.org/10.1038/s41556-021-00776-w (# equal contribution) Tsiairis, C.*, and Großhans, H.* (2021) Gene expression oscillations in C. elegans underlie a… Continue reading Publications
Grosshans Lab 