Home

Welcome to the Großhans Lab at FMI. We use C. elegans and mammalian cells to study mechanisms and function of oscillatory gene expression, cell fate control mechanisms, and microRNAs. Read more here.

Research

The lab is interested in understanding the molecular and physiological functions of mechanisms that regulate gene expression. Our current major interests are linked to the three areas described in more detail below, namely Oscillatory Gene Expression, Cell Fate Control, and MicroRNAs. However, we are happy to let the data guide us and have thus also… Continue reading Research

Lab news

Apr 20th, 2018: Florian’s collaborative work with Rafal Ciosk’s lab reveals an unusual mode of RNA recognition by LIN41/TRIM71 – read the details here. Apr 14th, 2018: Closing date for applications to the International PhD Program of the FMI approaching fast (May 1st) – find details and apply here. Mar 21st, 2018: Giovanna’s work on miRNA… Continue reading Lab news

Publications

2018 Brancati, G., and Großhans, H. (2018). An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity. Nucleic Acids Res., doi:10.1093/nar/gky201 (NAR Breakthrough Article; Recommended Article: F1000Prime: doi:10.3410/f.733028808.793544522) de la Mata, M., and Großhans, H. (2018). Turning the table on miRNAs. Nature Struct. Mol. Biol. 25: 195–197 2017 Miki, T.S.#,*, Carl,… Continue reading Publications