Publications

2017

Miki, T.S.#,*, Carl, S.H. #, and Großhans, H.* (2017). Two distinct transcription termination modes dictated by promoters. Genes Dev. 31: 1870-1879. (# equal contribution)
(Highlighted in: Otto, Nat. Rev. Genet. (2017) doi:10.1038/nrg.2017.93;
Recommended Article: F1000: doi:10.3410/f.731980027.793540272)

Malone, B., Atanassov, I., Aeschimann, F., Li, X., Großhans, H., and Dieterich, C.* (2017). Bayesian prediction of RNA translation from ribosome profiling. Nucleic Acids Res. 45: 2960-2972.

Aeschimann, F., Kumari, P., Bartake, F., Gaidatzis, D., Xu, L., Ciosk, R., and Großhans, H.* (2017). LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms. Mol. Cell 65: 476–489.
(Highlighted in: Hand & Bazzini, Mol. Cell 65: 375-377;
Editor’s Choice: Sci. Signal 10: doi:
10.1126/scisignal.aam9537;
Recommended Article: F1000: doi:10.3410/f.727233850.793531470

2016

Miki, T.S., Carl, S.H., Stadler, M.B., and Großhans, H.* (2016). XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans. PLoS Genet. 12: e1006313.

Richter, H., Katic, I., Gut, H., and Großhans, H.* (2016). Structural Basis and Function of XRN2-Binding by XTB Domains. Nat. Struct. Mol. Biol. 23: 164-71.

2015

Aeschimann, F., Xiong, J., Arnold, A., Dieterich, C.*, and Großhans, H.* (2015). Transcriptome-wide measurement of ribosomal occupancy by ribosome profiling. Methods 85: 75-89.

Ecsedi, M., Rausch, M., and Großhans, H.* (2015). The let-7 microRNA directs vulval development through a single target. Dev. Cell 32: 335-44.

Rüegger, S., Miki, T.S., Hess, D., and Großhans, H.* (2015) The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Nucleic Acids Res. 43: 3344-57.

de la Mata, M., Gaidatzis, D., Vitanescu, M., Stadler, M.B., Wentzel, C., Scheiffele, P., Filipowicz, W.,* and Großhans, H.* (2015). Potent degradation of neuronal miRNAs induced by highly complementary targets. EMBO Rep. 16: 500-11.

Rausch, M.#, Ecsedi, M.#, Bartake, H., and Großhans, H.* (2015). A genome-wide screen reveals widespread function of cell cycle genes in let-7 miRNA activity. Dev. Biol. 401: 276-86. (# equal contribution)

2014

Miki, T.S.#, Rügger, S.#, Gaidatzis, D., Stadler, M., and Großhans, H.* (2014). Engineering of a conditional allele reveals multiple roles of XRN2 in C. elegans development and substrate specificity in microRNA turnover. Nucleic Acids Res. 42: 4056-67

Miki, T.S., Richter, H. #, Rüegger, S.#, and Großhans, H.* (2014). PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain. Mol. Cell 53: 351-560
(# equal contribution)

Hendriks, G.-J.#, Gaidatzis, D. #, Aeschimann, F., and Großhans, H.* (2014). Extensive oscillatory gene expression during C. elegans development. Mol. Cell 53: 380–392 (# equal contribution)
(Highlighted in Laxman, S. et al., Mol Cell 53:363-364;
Recommended Article: F1000: doi: 10.3410/f.718243173.793495536)

2013

Katic, I.* and Großhans, H.* (2013). Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans. Genetics 195: 1173-1176

Bossé, G.D., Rüegger, S., Ow, M.C., Vasquez-Rifo, A., Rondeau, E.L., Ambros, V.R., Großhans, H., and Simard, M.J.* (2013). The DeCapping Scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Mol. Cell 50: 281-287

Ecsedi, M., and Großhans, H.* (2013). LIN-41/TRIM71: Emancipation of a miRNA target. Genes Dev. 27: 581-589

Miki, T.S.*, and Großhans, H.* (2013). The multifunctional RNase XRN2. Biochem. Soc. Trans. 41: 825-830

2012

Rüegger, S., and Großhans, H.* (2012). MicroRNA Turnover: When, How, and Why. Trends Biochem. Sci. 37:436-246

2011

Hurschler, B.A., Harris, D.T., and Großhans, H.* (2011). The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans. Nucleic Acids Res. 39: 5647-5657

Chatterjee, S., Fasler, M., Büssing, I., Großhans, H.* (2011). Target-mediated protection of endogenous microRNAs in C. elegans. Dev. Cell 20: 388-396 (highlighted in Nat. Rev. Genet. 2011)

Filipowicz, W.*, and Großhans, H.* (2011). The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential. In Gasser, S., Li, E. (eds.) Epigenetics and Disease – Pharmaceutical Opportunities. Prog. Drug Res. 67: 221-238

2010

Jovanovic, M., Reiter, L., Picotti, P., Lange, V., Bogan, E., Hurschler, B.A., Blenkiron, C.; Lehrbach, N.J., Ding, X.C., Weiss, M., Schrimpf, S.P., Miska, E.A., Großhans, H., Aebersold, R., Hengartner, M.O.* (2010). A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nat. Methods 7: 837–842

Büssing, I., Yang, J.S., Lai, E.C., and Großhans, H.* (2010). The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila EMBO J. 29: 1830-1839

Großhans, H.*, and Büssing, I. (2010). MicroRNA biogenesis takes another single hit from microsatellite instability. Cancer Cell 18: 295-297 (Preview)

Großhans, H. (ed.) (2010). Regulation of microRNAs. Adv. Exp. Med. Biol. Vol. 700

Großhans, H.*, and Chatterjee, S. (2010). MicroRNases and the regulated degradation of mature animal miRNAs. Adv. Exp. Med. Biol. 700: 140-155

Großhans, H.*, and Müllner, A.E. (2010). MicroRNAs in C. elegans development. Mol. Med. Medicinal Chem. 1: 54-94

Hurschler, B.A., Ding, X.C., and Großhans, H.* (2010). Translational Control of Endogenous MicroRNA Target Genes in C. elegans. Rhoads, R.E. (ed.): miRNA Regulation of the Translational Machinery. Prog. Mol. Subcell. Biol. 50: 21-40.

2009

Chatterjee, S., and Großhans, H.* (2009). Active turnover modulates mature microRNA activity in C. elegans. Nature 461: 546-549
(Faculty of 1,000 “Must Read”)

Ding, X.C., and Großhans, H.* (2009). Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. EMBO J. 28: 213-222

Ding, X.C., Weiler, J., and Großhans, H.* (2009). Regulating the regulators: mechanisms controlling the maturation of microRNAs. Trend Biotechnol. 27:27-36

2008

Ding, X.C., Slack, F.J.*, and Großhans, H.* (2008). The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle 7: 3083-3090

Großhans, H.* and Filipowicz, W.* (2008). Proteomics joins the search for microRNA targets. Cell 134:560-562

Büssing, I., Slack, F.J., and Großhans, H.* (2008). let-7 microRNAs in development, stem cells and cancer. Trends Mol. Med. 14:400-409

Großhans, H.* and Filipowicz, W.* (2008). The expanding world of small RNAs. Nature 451:414-416

2007

Großhans, H.* and Svoboda, P.* (2007). miRNAs, siRNAs, piRNAs – Kleine Wiener Ribonukleinsäuren. Bioessays 29:940-943

Großhans, H.* (2007). An in vivo perspective on microRNAs: Lessons from the worm In: MicroRNAs: Biology, Function and Expression. Clarke, N.J., and Sanseau, P.X. (eds.), pp. 127-155, DNA Press, Eagleville, PA

2005

Großhans, H., Johnson, T., Reinert, K.L., Gerstein, M., and Slack, F.J.* (2005). The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev. Cell 8: 321-330

Johnson, S.M., Großhans, H., Shingara, J., Byrom, M., Jarvis, R., Cheng, A., Labourier, E., Reinert, K.L., Brown, D., and Slack, F.J.* (2005). RAS is regulated by the let-7 microRNA family. Cell 120: 635-647

2003

Neumann, S., Petfalski, E., Brügger, B., Großhans, H., Wieland, F., Tollervey, D., and Hurt, E.* (2003). Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep. 4: 1156-1162

2002

Großhans, H., and Slack, F.J.* (2002). Micro-RNAs: small is plentiful J. Cell Biol. 156: 17-22

Simos, G., Großhans, H., and Hurt, E. (2002). Nuclear export of tRNA. Results Probl. Cell Differ. 35:115-131

2001

Großhans, H., Lecointe, F., Grosjean, H., Hurt, E., and Simos, G.* (2001). Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. J. Biol. Chem. 276: 46333-46339

Galani, K., Großhans, H., Deinert, K., Hurt, E., and Simos, G.* (2001). The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J. 20: 6889-6898

Großhans, H., Deinert, K., Hurt, E. and Simos, G.* (2001). Biogenesis of the signal recognition particle involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. J. Cell Biol. 153: 745-762

2000

Großhans, H., Hurt, E., and Simos, G. * (2000). An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes Dev. 14: 830-884

Großhans, H., Simos, G., and Hurt, E.* (2000). Review: Transport of tRNA out of the nucleus – direct channeling to the ribosome? J. Struct. Biol. 129: 288-294

Großhans, H.* (2000). Gene therapy – when a simple concept meets a complex reality. Funct. Integr. Genomics 1: 142-145

 

*: Corresponding author