Research on developmental timing, cell fates and RNA
In Caenorhabditis elegans, the heterochronic pathway controls the timing of somatic cell development. This may be conserved across species, as several heterochronic genes have counterparts in mammals. The let-7 miRNA and its regulator LIN28 seem to regulate the start of puberty in mice and humans. – available as a preprint on bioRxiv
How to time differentiation into a sexually dimorphic nervous system? Florian’s collaborative work with Oliver Hobert’s lab shed light on the link between developmental timing and sexually dimorphic behaviors in C. elegans – available as a preprint on bioRxiv
Read more here
Florian’s collaborative work with Rafal Ciosk’s lab reveals an unusual mode of RNA recognition by LIN41/TRIM71 – read more here
Giovanna’s work on miRNA specificity and the effect of miRNA concentrations was designated “NAR Breakthrough Article and you can read it now online here.
Grosshans Lab 